Abstract
Gold nanoparticles are predominantly used in diagnostics, therapeutics and biomedical applications. The present study has been designed to synthesize differently capped gold nanoparticles (AuNps) by a simple, one-step, room temperature procedure and to evaluate the potential of these AuNps for biomedical applications. The AuNps are capped with glucose, 2-deoxy-D-glucose (2DG) and citrate using different reducing agents. This is the first report of synthesis of 2DG-AuNp by the simple room temperature method. The synthesized gold nanoparticles are characterized with UV-Visible Spectroscopy, Fourier transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM) and selected area electron diffraction (SAED), Dynamic light scattering (DLS), and Energy-dispersive X-ray spectroscopy (SEM-EDS). Surface-enhanced Raman scattering (SERS) study of the synthesized AuNps shows increase in Raman signals up to 50 times using 2DG. 3-(4, 5-dimethylthiozol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay has been performed using all the three differently capped AuNps in different cell lines to assess cytotoxcity if any, of the nanoparticles. The study shows that 2DG-AuNps is a better candidate for theranostic application.
Highlights
Application of nanotechnology has gained a major thrust in research especially in the area of medicine and biology
The present work has been designed to formulate a synthesis of a novel glucose capped gold nanoparticle which can be considered as a better theranostic candidate
Our present paper describes the synthesis of differently capped gold nanoparticles and characterization of the nanoparticles by different techniques
Summary
Application of nanotechnology has gained a major thrust in research especially in the area of medicine and biology. The gold supraparticles have nanoparticle building blocks in close contact that generate highly intense SERS signals They generate plasmonic heat more efficiently and kill more cancer cells than the constituent nanoparticle building blocks. These traits make the proposed crystallographically aligned supraparticles promising candidates for nanomedicine applications such as SERS -based diagnostics and plasmonics-based theranostics [21]. Synthesizing AuNps with lesser toxicity is one of the primary interests in the field of nanotechnology for its applicability in biomedical sciences Based on this perspective, the present work has been designed to formulate a synthesis of a novel glucose capped gold nanoparticle which can be considered as a better theranostic candidate. Evaluation of biocompatibility of the nanoparticles has been carried out using HeLa, HepG2 and HCT 116 cell lines
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