Abstract
The new methyl [3-(4-chlorophenyl)-2-{[(2,4-dichloro-1,3-thiazol-5-yl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-ylidene]acetate was synthesized from 4-(4-chlorophenyl)-1-(2,4-dichloro-1,3-thiazol-5-yl)methylidene-3-thiosemicarbazide using dimethyl acetylenedicarboxylate as thia-Michael reaction acceptor. New compounds (3 and 4) were characterized by IR, 1H and 13C NMR spectroscopy methods.
Highlights
Toxoplasmosis is a common parasitic infectious disease that occurs all over the world
We describe the synthesis of the previously unknown methyl
Discussion targeted compound was synthesized by three-step synthesis starting from
Summary
Toxoplasmosis is a common parasitic infectious disease that occurs all over the world. The currently used drugs are not 100% effective for the treatment of toxoplasmosis, and this has prompted us to look for new synthetic compounds that could be used to combat this common parasite in the future. In our previous research [12], we identified (4-oxothiazolidin-5-yl/ylidene)acetic acid derivatives with antiparasitic activity against T. gondii (Figure 1). We designed a compound which contains both highlighted fragments. In this communication, we describe the synthesis of the previously unknown methyl [3-(4-chlorophenyl)-2-{[(2,4-dichloro-1,3-thiazol-5-yl)methylidene]hydrazinylidene}-4-oxo-1,3-thiaz olidin-5-ylidene]acetate, which has potential as an anti-T. gondii agent. Molbank 2020, 2020, x FOR PEER REVIEW previously identified compounds with anti-T. gondii activity. 1. (4-Oxothiazolidin-5-yl/ylidene)acetic acidderivatives derivatives with anti-T. gondii activity and new designed compound
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