Abstract
Herein, the synthesis of the first example of a 3′‐deoxy‐5′‐phosphonate 2′[R] C‐nucleoside and its corresponding prodrug is presented. The developed route involves a reductive debromination at the 2′‐position of a suitably substituted 9‐deazaadenosine intermediate, followed by a stereoselective glycosylation at the 5′‐anomeric position to achieve the installation of the phosphonomethoxy functionality. The target compound with the desired configuration is formed upon base‐promoted epimerization at the 2′[S]‐position of the sugar moiety.
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