Abstract
AbstractThe organometallic precursor fac‐[99mTc(OH2)3(CO)3]+ was reacted with trimethyl‐bromoacetanilido‐iminodiacetic acid (mebrofenin) in phosphate buffered saline (pH 7) at 70°C for 1 h to produce the complex, 99mTc(CO)3‐mebrofenin, in >95% yields. High performance liquid chromatography analysis indicated the formation of a single species. In vitro studies of 99mTc(CO)3‐mebrofenin showed that the complex is stable for 24 h. No decomposition or alteration of the complex was observed in the presence of excess amount of cysteine and histidine. 99mTc‐mebrofenin was also prepared for comparative evaluation by the conventional method using a ready to use kit HPLC analysis of this complex showed presence of two species. Biodistribution studies in normal Swiss mice with 99mTc(CO)3‐mebrofenin showed hepatobiliary clearance. However, the retention in liver was higher (13% at 1 h p.i.) as compared to that of 99mTc‐mebrofenin (3.4% at 1 h p.i.). Copyright © 2003 John Wiley & Sons, Ltd.
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