Abstract
The synthesis of optically pure unsaturated carbocyclic nucleoside analogues is described. (3,4 S)-Bis( t-butyldiphenylsilyloxymethyl)-2-cyclopenten-1 R and 1 S-ol were coupled with 6-chloropurine and 2-amino-6-chloropurine respectively, using a modified Mitsunobu reaction. The products were reacted further using standard procedures to give compounds 12, 14, 16 and 18 which were tested for anti-HIV activity.
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