Synthesis of α-Allenic Esters (Acids)

Abstract

This article focuses on the synthesis of a-allenic esters (or alkane-2,3-dienoates) and their corresponding acids, but does not claim to present all of the synthetic methods of this type of compounds. A brief account dealing with the asymmetric synthesis of α-allenic esters is also presented. I Introduction 2 Synthesis of a-Allenic Esters (Acids) 2.1 From Propargyl Derivatives 2.2 From Palladium-Catalyzed Reactions of Propargyl Compounds 2.3 From Horner-Wadsworth-Emmons and Wittig Reactions 2.4 Via Sigmatropic Rearrangements 2.5 From Organometallic Reagents 2.6 From Acetylenic Derivatives 2.7 From p-Keto Esters and ω-Keto Esters 2.8 Via Flash Vacuum Thermolysis (FVT) 2.9 From gem-Difluorocyclopropene 2.10 Miscelleanous 3 Asymmetric Synthesis 4 Conclusion.