Abstract

Dioscin derivatives ( 1– 12) with a variety of substitutions at the 6′-OH of the chacotriosyl residue and the 3′,6′-anhydrosaponin derivatives ( 26, 30, and 32) were synthesized. All these derivatives showed much lower cytotoxicity than that of the parent dioscin, while their hemolytic activities were partially retained depending on the various 6′-O-substitutions.

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