Abstract
A new complex associated with Cd2+, [Cd(OH-H2Bdc)(2-Pbim)]n (1), (OH-H2Bdc = 5-hydroxyisophthalic acid, 2-Pbim = 2-(2-pyridyl)benzimidazole), has been synthesised under hydrothermal conditions and characterised by elemental analysis, FT-IR spectroscopy, TG/DTG and fluorescence spectrum. Its in vitro cytotoxicity towards four selected tumour cell lines has been evaluated by an microculture tetrozolium assay, the results suggest that complex 1 displays greater inhibition than the free benzimidazole ligand. On the basis of the combination of absorption titration and fluorescence emission titration, the binding mode of complex 1 to calf thymus DNA has been investigated. Complex 1 can interact with the base pairs of double-helical DNA via the combined mode of intercalation and groove binding with larger binding constants.
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