Abstract
Abstract In the present investigation, we focused our interest on the synthesis of 1, 4, 5-disubstituted 1, 2, 3-triazoles ethanone derivative through metal free cycloaddition reaction and their reduced ethanol derivatives. The structures of the compound were established on the basis of spectral data such as FTIR, multi nuclear NMR (1H &13C) and Elemental analysis. Estimation of the pharmacological potential (antimicrobial, antimycobacterial, anti-inflammatory and antineoplastic) of the synthesised compounds has been carried out on the basis Prediction of activity spectra for substances (PASS). Interestingly, PASS prediction of the compounds (5a-f) & (6a-f) showed that none of the synthesised compounds act as antineoplastic agents compared to standard CAI an potent antineoplastic agent (Pa Table 1 ).
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