Abstract
Two new chiral selenated Schiff bases have been synthesized on condensation of a chiral selenated amine, (R)-2-(benzylselanyl)-1-phenylethanamine with 3,5-di-tert-butyl-2-hydroxy benzaldehyde ((R)-L1H) and 2-hydroxy-3-methoxybenzaldehyde ((R)-L2H), respectively. Reactions of ligands (R)-L1H and (R)-L2H with Na2[PdCl4] yielded the corresponding palladium complexes [PdCl((R)-L1–2)] ((R)-1 and (R)-2), respectively. The new ligands and complexes were characterized by 1H, 13C{1H} NMR, FT-IR spectroscopy and elemental analyses. The molecular structures of ligand (R)-L1H and its Pd complex (R)-1 were determined by single crystal X-ray diffraction. These selenated Schiff base ligands and their palladium complexes have been screened for dose-dependant antimicrobial and antithrombotic activities. Among these compounds, the ligand (R)-L2H and its Pd complex (R)-2 which are derived from ortho-vanillin showed higher antimicrobial and antithrombotic activities.
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