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Abstract
Objective: Hypertension is one of the major causes of the cardiovascular diseases and in the later stages, it also damages the brain, kidneys, eyes and coronary arteries. It is also life threatening as it causes heart strokes and attacks. The calcium channels regulates blood pressure by muscle contraction triggered by neurotransmitter release to electrical excitation. Method: Calcium channel blocker drugs reduce intracellular calcium transfer to limit ATP release to reduce muscle cell contractility. They act, especially on the nodal tissues in the heart and arterial smooth muscle cells in which only slow calcium channel blockers opens without triggering of fast sodium ion channels. Pharmacophore approach is employed to generate novel thiosalicylamide derivatives having calcium channel blocking activity for treatment of hypertension. Result: These novel thiosalicylamide derived lead molecules are synthesized and tested for their in-vivo pharmacological activity by using isolated guinea-pig ileum muscles.
Published Version
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