Abstract
6(2-Chloro 3,5-substituted phenyl)-1,2,4-triazine derivatives were synthesized and studied for evaluation of anticonvulsant activity by maximal electroshock test and neurotoxicity by rotarod motor test. Some compounds were displayed protection against induced seizures at a dose level 100 mg/kg after 0.5 and 4.0 h and while some compounds were displayed neurotoxicity at highest administered dose (300 mg/kg) after 4.0 h. Screening data revealed that one compound was found most active in series with little CNS depressant effect without neurotoxicity when compared to standard drugs Phenytoin and Carbamazepine.
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