Abstract
The synthesis and characterization of Co(II) and Ni(II) mixed ligand complexes are derived from isoniazid, 9-fluorenoneandoxalate. The metal complexes were characterized on the basis of elemental analysis, IR, UV-visible, CV, PXRD, and molar conductance analytical data, viz., all the metal complexes were suggested in an octahedral geometry, respectively. The mixed ligand complexes are formed in the 1:1:2:1 (M:L1:L2:L3) ratios, as found from the elemental analyses, and originate to have the formula [M(L1)(L2)2(L3)]. Where M = Co(II), Ni(II), L1 = isoniazid, L2 = 9-fluorenone, and L3 = oxalate. The molar conductance data reveals that the complexes are non-electrolytes. The cyclic voltammogram of the Co(II) complex revealed that the quasi-reversible single electron transfer process and Ni(II) complex corresponding to a one-electron transfer process were observed during controlled potential electrolysis. IR spectra show that the ligands are coordinated to the metal ions through N and O donor sites of isoniazid-N, 9-fluorenone-O and oxalate-O. Magnetic moment values and UV-visible spectra were used to infer the coordinating of the geometrics of these complexes found to be octahedral. The PXRD patterns suggest that all the complexes are crystalline phases. The metal chelates have been screened for antimicrobial, antioxidant and anti-inflammatory activities, and our findings have been reported, explained and compared with some known antibiotics.
Highlights
The mixed ligand–metal complexes are important fields of bioinorganics, medicine, chemistry, photochemistry, molecular biology, electromagnetism chemistry, etc. [1]
Metal ions are needed as medicines and diagnostic agents [6]
The current research focuses on the synthesis, characterization, antibacterial, antioxidant, and anti-inflammatory properties ofisoniazid, oxalate, and 9-fluorenone and their Co(II) and Ni(II) mixed ligand complexes
Summary
The mixed ligand–metal complexes are important fields of bioinorganics, medicine, chemistry, photochemistry, molecular biology, electromagnetism chemistry, etc. [1]. Researchers are more interested in metal-drug complexes because of their various medical applications in the treatment of ailments [5]. Transition metal compounds play such an important role in the creation of Co(II) and Ni(II) metal complexes as medicines for the treatment of a wide range of diseases in one of the most active fields of research. Isoniazid complexes have been found to be relatively stable and to have interesting biological properties. The INH contains donor atoms, such as nitrogen, oxygen, and carbonyl, and when they combine with metal ions, they form complexes with various geometries that are biologically active [9]. The current research focuses on the synthesis, characterization, antibacterial, antioxidant, and anti-inflammatory properties ofisoniazid, oxalate, and 9-fluorenone and their Co(II) and Ni(II) mixed ligand complexes
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