Abstract
Studies of coordinated compounds containing ruthenium (Ru2+ and Ru3+) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)3(H2O)2(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band λmax (ε= 1.685 × 103 L·cm-1·mol-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at δa (-COO-) 1664 cm-1, δs (-COO-) 1388 cm-1, δs () 1571 cm-1 and δs (CCN) 889 cm-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115°C (TG = 12.18%; Calculated = 11.32%) H2O (coordinating water), exothermic peaks at 230°C, 307°C, 440°C and 463°C due to oxidative decomposition of glycine, followed by the formation of RuClO residue at 665°C (TG = 41.11%; Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl3(H2O)2(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 μg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.
Highlights
Metals and inorganic compounds have been used in medical therapies since the sixteenth century (Sadler, 1991; Abdel-Rahman, 2013; Abdel-Rahman, 2016) [1] [2] [3]
The literature shows that ruthenium-glycine compounds exhibit absorption in the 290 nm region, little intense, as characterized as ligand metal charge transfer (LMCT)-type interactions (Load Transfer Ligand Metal) between the oxygen of the carboxyl group and metallic ion (Yeh and Taube 1980) [24]. the band found in the ultraviolet region at 230 nm, can be attributed to internal transitions of the ligand (IL), and were very similar in intensity to electronic transitions π - π* free ligand (Bento and Tfouni 1988) [25]
With the analysis of the compound in the infrared region, it was possible to determine the shape of connection between the glycine ligand and metal ruthenium
Summary
Metals and inorganic compounds have been used in medical therapies since the sixteenth century (Sadler, 1991; Abdel-Rahman, 2013; Abdel-Rahman, 2016) [1] [2] [3]. Evidence suggests that several ruthenium complexes interact with specific proteins One such application is the use of red ruthenium, which is traditionally used as a cytological stain for electron microscopy. In this case, binding of the compound occurs in the anionic sites of calcium-binding proteins (Clarke 2003; Suriano et al 2005) [8] [9]. It was observed that several compound Ru2+ and Ru3+ amine ligands tend to interact selectively the carbonyl and imino sites of biomolecules that do not protonam at neutral pH This leaves the pairs of electrons (of Nitrogen) available to coordinate bond with metal ions. A biological analysis of the effectiveness of the ruthenium compound in treating an experimental model of leishmaniasis was carried out
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