Abstract
Several novel quinazolinones were designed and synthesized from anthranilic acid by a multistep synthesis. Structures of synthesized compounds were well characterized using FT-IR, 1H-NMR, Mass spectroscopy and bases of elemental analysis. Entire test compounds were screened for their antibacterial and antifungal activities by agar streak dilution test against various pathogenic strains of bacteria and fungi. Antimicrobial studies revealed that all title compounds exhibited mild to good antibacterial activity and mild to moderate antifungal activity. The relationship between the functional group variation and the biological activity of the screened compounds were discussed. Out of thirteen tested analogs, the most active compound was found to be 3-(2-(1-(4-chlorophenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene) hydrazinyl)-2-methylquinazolin-4(3H)-one VIIg.
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