Abstract
As is known, N-benzyl-1,2,3,4-tetrahydroisoquinoline derivatives are capable of influencing the blood coagulation process [1, 2]; tiklyd, representing a thiophene analog of N-benzylisoquinoline, is a selective antiaggregant with respect to thrombocytes [3, 4]. While compounds of the 1-benzylisoquinoline series were reported to exhibit hypotensive properties [3 – 8], this activity was not studied for 2-benzylisoquinolines (i.e., N-derivatives of the heterocycle). A comparison between properties of the two groups of isoquinoline derivatives would elucidate the dependence of their pharmacological properties on the position of the benzyl radical in the molecule. N-Benzylisoquinolines (IIIa – IIIg) were synthesized via reduction of the corresponding amides (IIa – IIg) with lithium aluminum hydride. The initial amides were obtained via benzoylation of compound I in the presence of triethylamine [9]:
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
