Abstract
Fifteen mixed cis-diamine complexes cis-[Pt(Mor)(Am)Cl2], Mor: morpholine; Am: aniline, o-toluidine, p-toluidine, p-anisidine, p-phenetidine, α-naphthylamine, pyridine, quinoline, 8-oxiquinolinato, benzylamine, 2-phenylethylamine, methylamine, dimethylamine, ethylamine and diethylamine have been prepared. The structures of the complexes have been examined by elemental analysis, molar conductivity, UV, IR, Raman and 1H NMR spectra. Spin–spin splitting patterns of non-equivalent protons of morpholine have been designated. The morpholine ring has a chair conformation with nitrogen bound equatorially to Pt. The examined complexes have a cis-configuration in which the planes of the aromatic amine and morpholine rings are perpendicular to the coordination plane of Pt(II). The complexes were tested for cytotoxicity: cis-[Pt(Mor)(PhCH2NH2)Cl2], cis-[Pt(Mor)(PhCH2CH2NH2)Cl2] and cis-[Pt(Mor)(OC9H6N)Cl] exhibit anticancer activities in vitro on human cancer cell Hep-G and RD with IC50<5 µg cm−3.
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