Abstract
The copper based metal complexes (CMC) were synthesized using 1-phenyl-1,3-butanedione with two different solvents, methanol and water:acetic acid. The X-ray structural analysis of the two CMCs indicates that, coordination environment around the complex 1 [Cu(C10H10O2)2(CH4O)] exhibits distorted square-pyramidal geometry with trans-isomer favored structure whereas complex 2 [Cu(C10H10O2)2] exhibits distorted square-planar geometry with cis-isomer favored structure. Both copper complexes were characterized by SEM, EDX, Mass and TGA. Further, the CMCs were showed promising antibacterial activity by disc diffusion and minimum inhibitory concentration assay against Gram positive and Gram negative bacteria. The studied model showed CMC were potent against methicillin-resistant Staphylococcus aureus (MRSA) validated by inhibition of electron transport chain. The formation of membrane pore/damage by CMC leads to changes in the bioelectrochemistry of the MRSA was assessed and mechanism involved in membrane damage was confirmed by SEM. The study concludes that the complex 1 showed potent antibacterial action compared to standard drug ampicillin.
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