Abstract
The synthesis of new aliphatic analogs of the 2-phenylethylammonium salt of 2-phenylethylamide of o-sulfinobenzoic acid was accomplished. This furthered the study of the influence of sulfinic acid on anti-radiation activity and the search for more effective anti-radiation agents. Various compounds were synthesized, including fluorinated salts and unfluorinated analogs for comparitive tests. The toxicity of the compounds investigated was studied using white hybrid mice. It was determined that the combination of 1,2-oxathiolan-5-on-2-oxides with arylethylamines permits a decrease in the toxicity of the latter with the retention (or increase) of their radioprotective activity. Among the alkanesulfinates studied, the most promising anti-radiation compounds are C-arylethylamides based on isobutyric acid. 5 refs., 2 tabs.
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