Abstract
The hydrochloride of 4-aminopyridine is a curare antagonist with analeptic properties and this drug is used abroad under the name "pimadin" [I]. The mechanism of the action of pimadin is still not clear, and is the subject of conflicting opinions [1-3]. In spite of the difference between pimadin and anticholinesterase preparations such as proserine and galanthamine, pimadin possesses a similar mode of action for the restoration of synaptic transmission in skeletal muscles [4]. Intravenous injection of therapeutic doses of the preparation eliminates or lowers the narcotic action of diazepam and causes a fourfold reduction in the length of time for recovery from narcosis caused by a mixture of diazepam and nitrous oxide; it also acts as an antagonist to nonpolarizing myorelaxants [5].
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