Abstract

Three pyrimidinylpropanamide antibiotics sparsomycin ( 1), sparoxomycins A1, A2 ( 2, 3), and also six analogues ( 4–9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin ( 1) and its alkyl analogues ( 5–7) showed higher morphological reversion activities on src tsNMR cells than 2 and 3.

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