Abstract
ABSTRACT A series of biologically active Mannich bases with heteroaromatic ring system have been synthesized employing Mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3H-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. They were analyzed by elemental analysis and characterized by spectral studies- UV, IR, 1 H NMR, Powder X-ray diffraction and Scanning Electron Microscopy. The Mannich bases were screened for their antibacterial activity against various gram + and gram - bacteria. The results had shown that the Mannich bases are quiet active against pathogens under study at varying concentrations. The toxicity of synthesized Mannich bases was ascertained by LD 50 test. Key words : 2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one (Ganciclovir), Sulphonamides, Mannich reaction, Mannich bases, Antibacterial activity , LD 50 test. e-mail- sheelajoshi2010@gmail.com 1. INTRODUCTION Heterocyclic compounds are of immense biological and industrial importance, Majority of pharmaceuticals are heterocyclic
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