Abstract
The first example of DNA metallointercalator containing an oligopeptide moiety is presented. The ternary cobalt(II) complex [(DOTA)Co(II)(TPY)](ClO 4) 2 (DOTA=1,4,7,10-tetraaza-cyclododecane-2,9-dione, TPY=2, 2′:6′,2″-terpyridine) was found to be efficient in binding ct-DNA. The binding constant was determined by spectrophotometric titration. In vitro antitumor studies shows that this complex has significant antitumor activity. The single-crystal of a six coordinated oligopeptide cobalt(II) complex [Co(II)(DOTA) 2](ClO 4) 2 is also reported. The stabilities and species distributions of Co(II)–DOTA (1:1) and DOTA–Co(II)–TPY (1:1:1) systems were investigated by potentiometry titration.
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