Abstract
Assessment of cytotoxicity, antibacterial activity and phytochemical screening of ethanol extract of Phyllanthus acidus L. (family: Euphorbiacceae) BarkSubrata Kumar Biswas, Anusua Chowdhury, Joysree Das, Utpal Kumar Karmakar, Manik Chandra Shill, Sheikh Zahir Raihan
Highlights
The importance of organophosphorus compounds as intermediates in organic synthesis is well documented
The organic synthesis with participations of phosphorylated allenes lead to the formation of five- or six-membered phosphorus heterocycles with certain biological activity (Enchev, 2010)
Br-oxph-1 represents a newly synthesized by us structural analogue of a cytotoxic and genotoxic Br-oxph
Summary
The importance of organophosphorus compounds as intermediates in organic synthesis is well documented. Phosphorus heterocycles have received considerable interest because of their possible therapeutic application, including uses as genotoxic and anticancer agents (Hudson and Keglevich, 2008). Among other promising synthetic protocols, the heterocyclization of phosphorylated allenes has been established as one of the most fruitful ones. The combination of double bonds and a phosphoryl group in the molecules of those compounds, each with different reactivity, makes them useful substrates for the synthesis of different organophosphorus compounds. The organic synthesis with participations of phosphorylated allenes lead to the formation of five- or six-membered phosphorus heterocycles with certain biological activity (Enchev, 2010)
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