Synthesis and Characterization of some new 2,5-disubstituted- 1,3,4-oxadiazole derivatives Containing Antipyrine moiety.

Abstract

Some new 2,5-disubstituted-1,3,4-oxadiazolels of type (E)-4-((1-(5-(substitutedphenyl)
 1,3,4-oxadiazol-2-yl)pro-1-en-2-yl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-
 one were synthesized in (60-81%) yield under solvent free conditions using grinding
 technique through the reaction of hydrazide intermediate with benzaldehyde or different
 substituted benzaldehydes in the presence of catalytic amounts of iodine molecular as a
 single step. The structures of all the synthesized compounds were confirmed on the basis
 of their physical properties, IR, 1H-NMR and Mass spectral data.