Synthesis and Characterization of Some Bromochalcones Derivatives

Abstract

Chalcones are considered to be precursors of flavonoids and have variety of biological activities. Three of bromochalcones derivatives were synthesized by a green chemistry approach using grinding technique and their structure also confirmed. Synthesis of bromochalcone, 4′-bromo-4-methoxychalcone, 4′-bromo-3, 4-dimethoxychalcone, 4′-bromo-3, 4, 5-trimethoxychalcone were carried out using starting material of 4-bromoacetophenone through Claisen-Schmidt base catalyzed condensation. The structures of the synthesized compounds were confirmed by gas chromatography–mass spectrometry (GC-MS). The mass spectra of the compounds were showed corresponding molecular ion peak which was correlated with their molecular weight of that respected compound (4′-bromo-4-methoxychalcone = 317, 4′-bromo-3, 4-dimethoxychalcone = 347, 4′-bromo-3, 4, 5-trimethoxychalcone = 377).