Abstract
Abstract Fourteen new a-aryl-N-(2-phenylthiophenyl)nitrones have been synthesized. The spectral features reveal that the a-aryl and N-aryl rings are trans to each other and deviate from the plane. (2-Hydroxyphenyl)-N-(2-phenylthiophenyl)nitrone has a conformation in which the hydroxy group is closer to nitrone oxygen and other α-2-substituted phenyl-N-(2-phenylthiophenyl)nitrones prefer a conformation in which the 2-substituent of the α-aryl ring is away from the nitrone oxygen. The antimicrobial studies of these compounds reveal that while α-(2-methoxyphenyl)-N-(2-phenylthio-phenyl)nitrones is moderately active against Shigella flexneri and the α-(2-hydroxyphenyl)-N-(2-phen-ylthiophenyl)nitrone is moderately active against Staph. aureus, Shigella flexneria and S. typhi “H”.
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