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Abstract
A series of new derivatives of benzo[h]quinazolines containing diethyl substituents at position 5 were synthesized. The alkylation of some 2-substituted 5,5-diethyl-4-oxo-3,4,5,6-tetrahydrobenzo[h]quinazolines with methyl iodide led to N-substituted products, while a similar reaction with ethyl iodide led to a mixture of N-substituted and O-substituted products. Some of the synthesized 5,5-diethyl-4-oxo-3,4,5,6-tetrahydrobenzo[h]quinazolines exhibit pronounced antiaminooxidase and weak antitumor properties.
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