Abstract
A cationic porphyrin derivative namely, 5-carboxymethyleneoxyphenyl-10,15,20-tri(p-N-methylpyridyl)porphyrin was synthesized and conjugated with a bi-functional chelating agent namely, p-NH2-benzyl-DOTA (p-aminobenzyl-1,4,7,10-tetraazcyclododecane-1,4,7,10-tetraacetic acid). The porphyrin-p-NH2-benzyl-DOTA conjugate was radiolabeled with 177LuCl3 with a radiochemical purity of >95 %. Preliminary biological evaluation of the radiolabeled conjugate, carried out by bio-distribution studies in fibrosarcoma tumor bearing Swiss mice indicated rapid accumulation of the radiotracer in the tumor with fast clearance of the non-accumulated activity through renal pathway. However, the initially accumulated activity in the tumor exhibited fast clearance which could be attributed to its highly hydrophilic nature.
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