Synthesis and Antiproliferative Activity of New Copper, Cobalt, and Zinc Complexes with Abiraterone Acetate

Abstract

New complexes CuCl2[AbAc]2 (I), CoCl2[AbAc]2 (II), and ZnCl2[AbAc]2 (III) with abiraterone acetate (AbAc) are synthesized. The molecular structure of complex II is determined by X-ray diffraction (XRD) (CIF file CCDC no. 2252346). The cobalt atom coordinates with abiraterone acetate due to the N‑donor pyridine atom. The model processes of hydrolysis of the compounds in acidic and neutral media and their ability to interact with the superoxide radical anion generated in the xanthine–xanthine oxidase enzymatic system are studied. A high activity of complexes I and II is found. The MTT test shows that the antiproliferative activity of compounds I–III against the HCT-116, MCF-7, A-549, and WI-38 cells is comparable with the activity of cisplatin and exceeds that of the initial AbAc for the PC-3 cell line. Complex II also induces cell cycle arrest in the G0/G1 phase of RNA protein synthesis.