Abstract
The interaction of thiourea with activated cyanoolefins under different reaction conditions were studied, in which a variety of thiopyrimidines (8, 9, 12, 18, 20, & 21) and related derivatives (10, 11, 14, 16, & 17) were obtained respectively. Also, the reactions of thiopyrimidines (8, 9) with different electrophilic and nucleophilic reagents were reported. IR, 1H NMR, 13 C NMR and mass spectra for the newly synthesized compounds were studied. Most of the obtained compounds were screened against Gram-postive and Gram-negative bacteria and fungi, for which some of these derivatives gave promising results.
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