Synthesis and Antimicrobial Activity of 3‐Cyano‐4‐imino‐9‐methoxy‐4H‐pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2‐Substituted Derivatives

Abstract

The 2‐amino‐7‐methoxypyrimido[4,5‐b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3‐cyano‐4‐imino‐9‐methoxy‐2‐methythio‐4H‐pyrimido[2,1‐b]pyrimido[4,5‐b]quinoline (3). The latter were further reacted with selected N‐, O‐, and C‐nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group.