Abstract
A series of 4-(2-methoxyphenyl)-2-oxo-butyl-quinazolinones were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by H NMR, C NMR, IR spectra and HRMS. The biological activity test results indicated that they exhibited anticoccidial activities against Eimeria tenella in the chicken diet with a dose of 9 mg/kg. Compared with halofuginone, these compounds have the advantages of shorter synthetic routes and lower cost.
Highlights
Coccidiosis is an intestinal infection caused by protozoan parasites of the genus Eimeria, especially for broilers and turkeys, which occurs all over the world and leads to extensive loss in the poultry industry.[1]
Compared to other anticoccidial drugs, halofuginone has a higher anticoccidial activity when administered to chickens in the diet with a concentration of 3 mg/kg
The halogen groups could reduce the activity of anthranilic acid, which requires a high temperature in this step. 4-(2-Hydroxyphenyl) butan-2-one can be synthesized by reduction of (E)-4-(2-hydroxyphenyl) but-3-en-2-one (3) with H2/Pd/C (5 %) in ethyl acetate
Summary
Coccidiosis is an intestinal infection caused by protozoan parasites of the genus Eimeria, especially for broilers and turkeys, which occurs all over the world and leads to extensive loss in the poultry industry.[1]. The anticoccidial activities of the new compounds were evaluated according to the Anticoccidial Index (ACI) method.[10,11,12] quinazoline ring
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