Abstract
Summary A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino- and 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human bacterial flora. Biological tests showed that 5-[1-(4-chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino and 2-(1-piperazinyl)-4,6-dichloropyrimidine derivatives display a great selectivity against Corynebacterium xerosis and Arcanobacterium haemolyticum of the human axilla.
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