Abstract

The synthesis of a new series of 1<TEX>$\beta$</TEX>-methylcarbapenems having 5-(<TEX>$\alpha,\beta$</TEX>-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having <TEX>$\alpha$</TEX>-hydroxy-<TEX>$\beta$</TEX>-piperazinylethyl substituted moiety showed the most potent activity.

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