Abstract
A series of novel derivatives of dehydroabietylamine were synthesized by introducing some groups with good free radical scavenging activities into the dehydroabietylamine, such as hydrazone, gallic acid, oxime and isoniazid. Structures of the synthesized compounds were characterized by IR, H NMR, C NMR, MS and HRMS techniques. All the compounds were tested the ability on scavenging superoxide anion radical ( 2 O ) and 1,1-dipheny-2-picrylhydrazyl (DPPH•). The results indicate that the inhibitory rate of O by (6) (38.18%) is twice as much as that of Vc (18.35%), and its capacity on scavenging DPPH• (IC50=0.002×10 mg/L) is much better than Vc (IC50=0.236×10 mg/L.
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