Abstract
Ritter cyclocondensation of 2-(1-naphthyl)-1,1-(R1)2-ethanols [R1 = Me, 2R1 = (CH2)4] with nitriles of general formula R2CN (acetonitrile, benzonitriles, benzyl cyanide, cyanoacetamides) and subsequent treatment of the obtained bases with HCl synthesized a series 2,2-(R1)2-4-R2-1,2-dihydrobenzo[f]isoquinolinium chlorides. All 10 compounds showed analgesic (antinociceptive) activity in the hot-plate test, exceeding the defensive reflex time of metamizole sodium by 1.7 – 2.5 times. Also, they all exhibited anticonvulsant activity and prevented death from camphor-induced convulsions (28.6 – 100%).
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