Abstract
Two mononuclear Schiff base complexes, [Zn(L)2] (1) and [Cu(L)2] (2) are synthesized involving bidentate N,O-donor ligand viz. 2-((E)-(3-methoxypropylimino)methyl)-6-methoxyphenol. Different spectroscopic tools like FTIR, UV–Vis, 1H NMR, 13C NMR etc. have been deployed to characterize complexes 1 and 2. Complex 1 has been analyzed using single crystal X-ray diffraction analysis method. Complexes 1 and 2 show affinity towards A-T rich sequence of DNA which is further supported by molecular docking analysis. Interestingly, only complex 2 exhibits oxidative DNA cleavage activity in presence of H2O2 which is investigated by gel electrophoresis method. Complex 1 is found to be nontoxic whereas complex 2 is cytotoxic.
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