Abstract

The selective acetylation of 17α, 20, 20, 21-BMD-pregnan-5α, 6β, 11β-triol-3-one (IV), derived from cortisone, was led to its 6β-acetate (V). A solution of V in CHCl3 containing EtOH (0.7%) was treated with HCI gas to give 17α, 20, 20, 21-BMD-4-pregnene-6α, 11β-diol-3-one-6-acetate (VIa) and in pure CHCl3 to give 6β-derivative (VIb). The hydrolysis of 6-O-acetate of VIa with K2CO3 followed by succinylation with succinic anhydride gave 17α, 20, 20, 21-BMD-4-pregnene-6α, 11β-diol-3-one 6-hemisuccinate (VIIIa). 6α-Hydroxy- cortisol 6-hemisuccinate (IXa) was obtained by the hydrolysis of the bismethylenedioxy protecting group in VIIIa with 50% AcOH. 6β-Hydroxycortisol 6-hemisuccinate (IXb) was also obtained from VIb by the same procedure.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.