Abstract
isochromen-1-one, montmorillonite K-10. The isochromen-1-one skeleton is found in a variety of natural products [1]. Isocoumarins and their derivatives, such as dihydroisocoumarins, are secondary metabolites of a wide variety of microbial, plant, and insect sources and are used in the synthesis of other medicinal compounds [2-4]. Most methods available for the construction of 3-substituted 3,4-dihydroisochromen-1-one nucleus suffer from one or more drawbacks, such as the multistep procedure [5] and use of expensive and hazardous reagents and solvents. Many studies on isocoumarin synthesis, including cyclization of keto acids and electrophilic cyclization of alkynylbenzoic acid derivatives, have been reported [6, 7]. Finding an efficient method for the synthesis of 3,4-dihydroisochromen-1-one is still a challenge.
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