Abstract
AbstractMethyl‐2 p‐chlorophenyl‐4 pentane diol 2,4 14C‐4 (Rd 292‐Fenpentadiol), a psychotropic drug, was prepared by means of the action of methyl magnesium iodure on p‐chlorophenyl‐3 hydroxy‐3 ethyl butyrate 14C‐3. The latter was obtained by means of the Reformatzri reaction between ethyl bromoacetate and p‐chloroacetophenon 14CO, which was obtained by the action of iodhydric acid on p‐chlorophenyl diazoacetophenon 14CO, resulting from the action of diazomethane on p‐chlorobenzoyl 14C chlorure. The necessary p‐chlorobenzoic carboxyl 14C acid was obtained through carbonatation of p‐chlorphenyl magnesium bromure, free from any isomere a or m. The total yield compared to 14CO3Ba was 31% Specific activity : 25, 3 mCi/mM.
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