Abstract
On the basis of the novel concept of a dual prosecretory/antisecretory intestinal opioid system, a voltage-clamp experiment was performed with guinea-pig colonic mucosa, and net anion (Cl −) secretion was measured after stimulation with prostaglandin E 1 (PGE 1) plus theophylline. Synergism between κ-opioid receptor agonism by U69593 and μ-opioid receptor antagonism by CTOPNH 2 ▪ was observed.
Published Version
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