Abstract

Recently, reports from two clinics,1have appeared describing a syndrome developing in a small number of hypertensive patients treated with large doses of hydralazine (Apresoline) over a long period of time. This syndrome consisted of rheumatic manifestations varying in severity from fleeting mild arthralgias to full-blown arthritis and followed in a few patients, by febrile reactions and a clinical picture that showed remarkable resemblance to acute disseminated lupus erythematosus. Typical lupus erythematosus (L. E.) cells were demonstrated in one patient in the sternal marrow1aand in two patients in the plasma,1Except for a case of pancytopenia,2these are the only reports of delayed toxicity of a serious nature attributed to hydralazine. The purpose of our presentation is to report the case of a woman in whom a clinical and laboratory picture developed that simulated acute disseminated lupus erythematosus. The condition developed after the patient was

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