Abstract
Cellular fibronectin mediates the adhesion of cells with the extracellular matrix and thus probably regulates tumor invasion. Evaluation of proliferating cell nuclear antigen expression and counting of silver nuclear organizer regions potentially assess proliferative fraction and biologic aggressiveness in several malignancies. We investigated the above markers’ prognostic value in 60 malignant melanomas of the skin. Deep Clark levels were statistically associated with discontinuous fibronectin staining pattern (SPII) ( P < .05) as well as with high proliferating cell nuclear antigen and silver nuclear organizer regions indexes ( P < .01 and P < .05, respectively). Fibronectin staining pattern (SPII) was frequently observed in thick melanomas ( P < .05). High proliferating cell nuclear antigen immunoreactivity positively correlated with mitotic activity ( P < .05), the presence of vertical growth phase ( P < .05), and increased silver nuclear organizer regions counts ( P < .05). Patients with continuous fibronectin staining pattern (SPI) and low proliferating cell nuclear antigen scores were unlikely to develop metastatic disease ( P < .01). Therefore, the simultaneous comparative assessment of these factors is very promising in predicting melanomas clinical evolution.
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