Abstract
Laryngeal squamous cell carcinomas represent the most frequent form (over 90%) of laryngeal cancer, but their association with renal tumors is rare; the literature most often reports the synchronous association of carcinoma of the larynx with carcinoma of the upper aerodigestive tract or with bronchial carcinoma. We report the case of a 60-year-old patient, who is followed for a clear cell carcinoma of the kidney, and in whom we made the diagnosis of a squamous cell carcinoma of the larynx. We illustrate through this observation the rarity and the epidemiological profile of this presentation with a broad review of the literature.
Highlights
The simultaneous occurrence of multiple primary malignant tumors (MPMT) is an old notion, but rarely occurs, it is a phenomenon first described by Billroth in 1889 [1]
Urologic carcinomas are most often associated with synchronous tumors of the digestive tract, breast and lung, the laryngeal localization of a synchronous primary tumor is rare
Warren and Gates (1932) were able to collect 40 cases of MPMT from 1078 autopsies of cancer patients, and they established the criteria for diagnosis of MPMT as follows: the existence of more than one primary tumor in different organs, or two or more primary tumors developed from different cell types within the same organ, with no notion of contiguity between the two tumors, with different metastatic pathways, so the diagnosis of metastasis must be excluded [3]
Summary
The simultaneous occurrence of multiple primary malignant tumors (MPMT) is an old notion, but rarely occurs, it is a phenomenon first described by Billroth in 1889 [1]. Urologic carcinomas are most often associated with synchronous tumors of the digestive tract, breast and lung, the laryngeal localization of a synchronous primary tumor is rare
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