Symbolic patterns of heart rate dynamics reflect cardiac autonomic changes during childhood and adolescence

Abstract

Symbolic dynamics derived from heart rate variability (HRV) is able to reflect changes of cardiac autonomic modulations in healthy subjects. It has been shown that linear measures of HRV in children and adolescents monotonically increase or decrease (depending on the measure) with age whereas non-linear measures show a local extreme value at the age of 7 to 9 years. In this study, the age-related variations of dynamical features of the R-R interval series during childhood and adolescence were addressed. In particular, the binary symbolic dynamics reflecting the sequence of acceleration (='1') and deceleration (='0') of heart rate was examined. The R-R interval series of 409 healthy children and adolescents (age range: 1 to 22 years, 220 females) was analyzed with respect to the regularity of binary patterns of length 8 using Approximate Entropy (ApEn). Binary patterns were grouped to patterns sets according to the level of their regularity as assessed by ApEn. Pattern sets containing regular binary patterns occurred more often with increasing age whereas irregular binary patterns occurred less often. Specific regular binary patterns show an unexpected behavior. They occurred fewest in the group 7 to 9 years. Furthermore, regular binary patterns occur more often during daytime whereas irregular binary patterns occur more often during nighttime. In conclusion, the analysis of binary symbolic dynamics is able to reflect age-related changes during childhood and adolescence in spite of the considerable reduction of information involved. As many binary patterns are linked to sympathetic or parasympathetic modulations of the autonomic nervous system e.g. spectral analysis of HRV may be complemented by this kind of analysis.