Abstract
Abstract SV40‐transformed weanling Syrian hamster kidney cells were exposed to long wavelength ultraviolet radiation in the presence of 8‐methoxypsoralen or angelicin. The number of viruses induced as a result of this treatment was quantitated on CV‐1P cells. The results indicate that angelicin, which is generally believed to form only monoadducts, is a potent viral inducing agent even when compared with 8‐methoxypsoralen (8‐MOP), which forms both monoadducts and crosslinks. At low radiation exposures 8‐MOP is more effective than angelicin; as the radiation exposure is increased angelicin is capable of inducing the same peak level of virus expression as was 8‐MOP. It appears that the induction of SV40 is a phenomenon possibly related to the repair of monoadducts.
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