Abstract
Rationale: Recent evidence shows that in chronic kidney disease (CKD), as in starvation, visceral adipose tissue (VAT) insulin sensitivity is reduced, in association with lower lipogenesis and increased lipolysis, contributing to promote energy availability. O-linked N-acetylglucosamine transferase (OGT) is a novel negative modulator of VAT insulin sensitivity which also promotes lipolysis and fat mass loss. Acylated ghrelin (AG) is a gastric orexigenic hormone and a relevant tissue-specific modulator of intermediate metabolism. It increases insulin signalling in skeletal muscle, while in it limits fat accumulation and reduces insulin signalling in the liver. The potential role of AG and OGT in VAT metabolism as well as their interaction in CKD is unknown.
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