Abstract
OBJECTIVE:We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends.METHODS:The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models.RESULTS:Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001–2006 and 2007–2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III–IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007–2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52–09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year.CONCLUSION:Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.
Highlights
In 2018, 354,864 new cases of lip and oral cancer (OC) and 92,877 new cases of oropharyngeal cancer were reported worldwide
Data of patients diagnosed with oral squamous cell carcinoma (SCC) (C02, C05 except C051-C052, and C06) and oropharyngeal SCC (C01, C051C052, C09, and C10) according ICD-O3 between 2001 and 2012 were extracted from the Hospital Cancer Registry of A.C. Camargo Cancer Center (ACCCC) [19]; the morphological codes (8050/3, 8070/3, 8074/3, 8076/3, and 8083/3) [19] for oral and oropharyngeal SCC were registered at the ACCCC with follow-up until December 31, 2017
The 5-year survival of patients with oral SCC remained unchanged (49.7%–53.1%), whereas that of patients with oropharyngeal SCC increased from 37.2% to 49.1%
Summary
In 2018, 354,864 new cases of lip and oral cancer (OC) and 92,877 new cases of oropharyngeal cancer were reported worldwide. The number of deaths from lip cancer and OC was 51,005, whereas that from oropharyngeal cancer was 51,005 [1]. In 2018, 19,898 new cases of lip cancer and OC were reported in Latin America and Caribbean countries [1], whereas 14,700 new cases were reported in Brazil [2]. A total of 9,180 individuals from Latin America and Caribbean countries and 4,629 from Brazil developed oropharyngeal cancer [1]. No potential conflict of interest was reported
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