Surgical treatment and prognostic analysis of thymoma

Abstract

Objective To explore the prognostic factors affecting the long-term survival of patients with thymoma. Methods The clinical data of 55 patients with thymoma who were treated with thoracic surgery in Gansu Provincial People's Hospital from January 2004 to January 2017 were retrospectively analyzed. The possible prognostic factors were analyzed by univariate analysis and multivariate analysis with Kaplan-Meier method and Cox proportional hazard model, respectively. Results Two cases were lost and 53 cases were followed up successfully. All 53 patients underwent surgery. All patients were followed up for 1 to 125 months, and the 1, 3, 5, 10 year survival rates were 71.1%, 56.7%, 39.3% and 23.3% respectively. The significant prognostic factors demonstrated by univariate analysis included age, clinical symptoms, tumor diameter, Masaoka staging, WHO histologic classification, completeness of resection, and chemoradiotherapy (P<0.01). According to multivariate analysis, the tumor type (HR=5.15, 95% CI: 1.573-16.883, P<0.05), tumor diameter (HR=5.53, 95% CI: 1.879-11.797, P<0.05), WHO classification (HR=13.23, 95% CI: 3.015-29.230, P<0.05), Masaoka staging (HR=5.18, 95% CI: 1.597-13.737, P<0.05) and chemoradiotherapy (HR=12.14, 95% CI: 2.979-49.503, P<0.05) are independent factors affecting the postoperative survival rate of thymoma. Conclusions Tumor diameter, tumor resection, WHO classification, Masaoka and postoperative chemoradiotherapy were independent prognostic factors. Key words: Thymoma; Tumor diameter; Tumor resection; WHO classification; Masaoka staging; Radiotherapy; Chemotherapy